Mice transgenic for PLA2G2A develop atherosclerosis and when macrophages from these mice are transplanted into atherosclerosis-prone knockout mice, either low density receptor Ldlr−/− or Apolipoprotein E (Apoe) −/−, atherosclerosis is enhanced [9], [10], [11], [12]. The gene discussed is APOE; the disease is atherosclerosis.