Fung et al. [26] reported a suboptimal PPV (as low as 10%) for LSM using FibroScan to diagnose true cirrhosis in 102 patients (median age, 41; range, 18–63 years) with active hepatitis B (median serum ALT, 89; range, 46–501 IU/L). This evidence concerns the gene GPT and hepatitis B virus infection.