In regards to the development of distant metastasis, systemic relapse from previously localized CRC (stages I to III) after complete surgical resection was more frequent in MT KRAS patients than in WT KRAS patients (38.7% vs. 19.1%); however, systemic metastasis was more frequent at the time of initial CRC diagnosis in WT KRAS patients than in MT KRAS patients (80.9% vs. 61.3%; P = 0.010). The gene discussed is KRAS; the disease is colorectal carcinoma.