TNNI3 and Asymmetric septal hypertrophy: The dominant R141Q mutation in exon 7 of TNNI3 gene (Figure1B), lies within the “minimum inhibitory sequence” (residues 137 to 148) region, was observed in two individuals with severe familial asymmetric septal hypertrophy (ASH+), with interventricular septum (IVS) thickness of 25 and 28 mm, respectively.