TNNI3 and hypertrophic cardiomyopathy: Interestingly, we found three heterozygous arginine to glutamine (R to Q) substitution at 3 positions 98, 141 and 162 in TNNI3 Figure1A, 1B, 1C, of these R98Q in exon 6 of TNNI3 gene is novel (Figure1A) observed in a 28 years old severe hypertrophic obstructive cardiomyopathy patient (HOCM) with interventricular septum (IVS) thickness of 25 mm and his 5 years old asymptomatic son, with the family history of sudden cardiac deaths (Figure2).