However, many studies have demonstrated that the local expression of endogenous BMP-2 in femoral head tissue was inhibited in the steroid-induced osteonecrosis of femoral head (GONFH), which leaded to significantly reduced functions of the MSCs in lesions, bone repair and reconstruction capacity, lack of timely repair of bone necrosis, and subchondral bone burden and mechanical dysfunction, and eventually contribute to in the femoral head collapse. This evidence concerns the gene BMP2 and familial avascular necrosis of femoral head.