However, there was no significant difference of the expression levels of PPAR-γ mRNA between the femoral head osteonecrosis with and without decompression, suggesting that the core decompression surgery didn’t have effect on the expression of PPAR-γ in femoral head osteonecrosis at the mRNA level (Figure 2A). Here, PPARG is linked to familial avascular necrosis of femoral head.