MUTYH and colorectal carcinoma: In biallelic MUTYH mutation carriers the colonic phenotype resembles that of AFAP, with onset in the fourth-fifth decade and a limited number of adenomas (30-100) that increase susceptibility to CRC (Venesio et al., 2004; Filipe et al., 2009); however, unlike AFAP, hyperplastic and sessile serrated polyps can be found in MAP (Boparai et al., 2008; Zorcolo et al., 2011).