In addition to transversions along APC resulting in stop codon formation and gene inactivation, somatic GGT to TGT transversions, giving rise to the G12C KRAS activating-mutation, were frequently detected in MAP CRCs (Lipton et al., 2003; Jones et al., 2004; Nielsen et al., 2009). This evidence concerns the gene APC and mutyh-associated polyposis.