Overall, this suggests that RXFP3 is involved in the central processing of sensory signals and supports the possible modulatory role of the relaxin-3/RXFP3 system in stress and anxiety [8], [17]–[19], feeding and metabolism [20]–[24] and arousal and behavioural activation [5], [7], [9], [25]. This evidence concerns the gene RXFP3 and Anxiety.