Together this proves dose-dependency and cell type-dependency of NRAS induced malignancies and adds further complexity to the earlier depicted NRAS induced AML versus CMML question, since the transplantation of a higher number of NrasG12D/G12D myeloid cells accelerated but did not transform the CMML condition induced by NrasG12D/+ cells [19]. Here, NRAS is linked to acute myeloid leukemia.