A correlation between constitutively active NRAS and myeloid cells has been described in several mouse models [17], [13], [14], [18] and T-cell upregulation upon increased NRAS expression is consistent with the T-cell reduction found in the Nras KO mouse model [12] as well as the induced acute T-cell lymphoblastic leukemia/lymphoma in the NrasG12D/G12D bone marrow transplantation model [16]. Here, NRAS is linked to T-cell acute lymphoblastic leukemia.