NFKB1 and familial pancreatic carcinoma: Our previous study has shown that emodin downregulated the activation and expression of NF-κB in SW1990 cell implantation induced pancreatic cancer [20], NF-κB analysis of the orthotopic tumor tissues in this study showed that emodin alone or combined with gemcitabine suppressed NF-κB expression and its activity in pancreatic cancer tissues.