While the lack of statistical significance for fibrosis or fatty infiltration may indicate a lack of statistical power in our study, it is to be expected that differences between SCN5A-mut-positive and SCN5A-mut-negative patients are relatively small, and that other parameters for structural properties are not different between both groups, given the fact that Brugada syndrome is generally regarded a primary electrical disease, i.e., a disease in which gross structural changes cannot be routinely detected with current cardiac imaging methods. Here, SCN5A is linked to Brugada syndrome.