NFE2L2 and malignant colon neoplasm: Although Akr1b8 displayed a strong expression in mouse colon cancer cells (Joshi et al., 2010) and was suggested to be a target gene for NF-E2 related factor 2 (Nrf2) transcription factor that controls intestinal detoxification response (Varady et al., 2011), its expression and regulation in healthy liver and intestine remained elusive.