AKR1B10 and cancer: Because AKR1B10 and Akr1b8 are not only detoxifying enzymes but also affect de novo fatty acids synthesis in cancer cells, it would be interesting to determine if and which of the enzymatic activities of AKR1B10 could be involved in adipose tissue homeostasis (Ma et al., 2008; Wang et al., 2009; Joshi et al., 2010).