The relevance of Kv7.1/KCNE1 channels for renal function is further underlined by the observation that KCNE1 knockout mice suffer from hypokalemia, urinary and fecal salt wasting, and volume depletion (Arrighi et al., 2001; Warth and Barhanin, 2002). This evidence concerns the gene KCNE1 and Hypokalemia.