Results show that HIV-1 displays a preference for TEM cells that is increasing over time (Figure 1B, compare columns showing mock, HSA− and HSA+) with enrichment ratios of 1.5, 1.9 and 2.3 in HIV-1-infected versus uninfected bystander cells at 24, 48 and 72 h post-infection. However, the phenotype does not fully account for HIV-1 selectivity as we find a significant amount of virus-infected Tnaïve and TIM cells, even though these subsets are less susceptible to productive HIV-1 infection compared to TEM cells (enrichment ratios of 0.7, 0.4 and 0.4 for Tnaïve and 1.1, 0.8 and 0.8 for TIM). Here, ALB is linked to HIV-1 infection.