CD4 and infection: Consistent with a critical contribution of NK-like cells for the priming of virus-specific CD4 T cell responses in Il10−/− mice, depletion of NK-like cells indeed partly abolished the protective effect of CD4 T cells observed in Il10−/− mice at day 14 post infection (Figure 5B), since αNK1.1 depleted Il10−/− mice showed a significantly increased viral burden compared to untreated Il10−/− mice (Figure S6A).