REL and open-angle glaucoma: Figure 2 shows the relationship between 11 targets and the 11 POAG related genes. Finally, these 11 targets of MSH6, REL, MSH2, EPAS1, VRK2, FBXO11, EFEMP1, RTN4, RAB1A, ACTR2, and CALM2 were located on chromosome 2: 46411503–65629132, which have been shown to be closely related to POAG.