In studies on prostate cancer, gossypol-induced B-cell lymphoma 2 (Bcl-2)-dependent autophagy and apoptosis through an increase in the level of the tumor protein 53 (p53) upregulated modulator of apoptosis (p53-upregulated modulator of apoptosis [Puma] and NAPDH oxidase activator [Noxa]) [9-11]. This evidence concerns the gene TP53 and prostate cancer.