TNFRSF10B and colonic neoplasm: Gossypol was also found to induce autophagy in breast cancer [12], and to suppress colon cancer by downregulating cyclin D1 expression, causing G0/G1 phase arrest and activating death receptor 5 (DR5; tumor-necrosis-factor-related apoptosis-inducing ligand receptor-2, or TRAILR-2)–mediated apoptosis [13,14].