CAV1 and open-angle glaucoma: In an attempt to identify causative variant for POAG in the CAV1/CAV2 genes, Wiggs et al. [31] had examined 50 Kb region flanking CAV1/CAV2 and identified 14 additional SNPs and 2 haplotypes (of which rs4236601 was not a part of) with modest effects on POAG.