The identified MYOC mutations involved in POAG in different ethnic populations include Pro370Leu, Gly367Arg, Arg158Gln, Gly252Arg, Arg272Gly, Asn 450 Tyr, Gln48His and Asp 384 Asn [11,20-26,35-37]. The gene discussed is MYOC; the disease is open-angle glaucoma.