Figure 4B shows the focal thinning of Bowman’s layer in granular dystrophy. Stromal expression of matrilin-2 was observed, mainly in the corneal granules (p=0.248, subepithelial; p=0.190, deep). In lattice type I corneal dystrophy cases, diffuse but intense immunoreactivity for matrilin-2 was found in the enlarged basal epithelial cells (p<0.0001; Figure 4C). Here, MATN2 is linked to lattice corneal dystrophy type I.