Loeys et al. [1] did not find distinguishing features in patients with MFS with or without a FBN1 mutation except for the presence of ectopia lentis, which was significantly higher in individuals with mutations in FBN1. A significant difference was observed between the clinical phenotype of patients carrying a missense mutation in 11th and 12th EGF-like domains compared with patients carrying a missense mutation in EGF-like domains 13–18. The gene discussed is FBN1; the disease is Marfan syndrome.