A plausible mechanism for the apoptosis caused by HSULF-1 over-expression is that the significant reduction in p-ERK and p-Akt is sufficient to block proliferation and promote apoptosis and cell death in H292 cells, as the anti-tumor drug periplocin does in another NSCLC, A549, through its blockage of ERK and Akt pathways[34]. This evidence concerns the gene SULF1 and neoplasm.