It follows that down-regulation of HSULF-1 would enhance tumor growth, and it has been shown that over-expression of HSULF-1 in tumor cell lines inhibits specific, relevant signaling pathways dependent on growth factors including FGF-2, HB-EGF, HGF, and VEGF[9,10,13,18,23,25]. Here, HBEGF is linked to neoplasm.