AKT1 and non-small cell lung carcinoma: These results indicate that the specific removal of 6-O-sulfate groups from extracellular HSPGs by HSULF-1 reduced the high level of constitutive ERK and Akt signaling in NSCLC cells, and this inhibition could be reversed by a brief pulse of sulfated heparin, which presumably counterbalanced the loss of sulfates and thus restored 6-O-sulfate-dependent signaling.