In 23 cirrhotic patients with hepatorenal syndrome, infusion of 200 ml of 20% human albumin solution followed by large-volume abdominal paracentesis resulted in IAP reduction from a median of 22 to 9 mmHg and a significant increase in creatinine clearance during the subsequent 12 h from 23 ml/min to 33 ml/min (p = 0.002) [36]. This evidence concerns the gene ALB and hepatorenal syndrome.