Quantitative assessment of indirect stroke area (volume of healthy tissue that correlates to volume of damaged, ischemic tissue not affected by post-ischemic consolidation and glial scar formation) 3 days after transient MCAO revealed a significant reduction of indirect stroke area (37.58%) in TLR2−/− mice compared with the control WT group (Figure 5A,C). Here, TLR2 is linked to stroke disorder.