TLR2 and Stroke: The co-localization was observed in activated microglial cells situated in ischemic and peri-infarct regions of the brain at 3, 7 and 14 days post-stroke, suggesting that microglia/macrophages upregulate TLR2 in early, as well as in more chronic phases, of the brain response to ischemic injury (Figure 1C,D).