In the later phase (14 days after transient MCAO), evolution of the ischemic lesion stagnated, and indirect stroke area in TLR2−/− mice remained significantly larger (29.07%) compared with the WT control group (3 days: WT, 57.82 ± 5.04, n = 10; TLR2−/−, 36.09 ± 4.04, n = 10, P = 0.004; 7 days: WT, 42.29 ± 3.24, n = 10; TLR2−/− 53.46 ± 2.19, n = 10, P = 0.010; 14 days: WT, 44.10 ± 3.08, n = 9; TLR2−/− 56.92 ± 5.43, n = 6, P = 0.049). Here, TLR2 is linked to Stroke.