Using several centrality indexes for hubs detection, some well know preeclampsia related genes like FLT1, TNF, VEGFA and PGF were detected as well as other genes with high scores, like PDIA3, NDRG1, TBK1, LYN, IQGAP1, DNM1, SAT1, MEN1 and SH2B2 that have been poorly explored or unknown in the current state of the art of preeclampsia physiopathology. The gene discussed is SH2B2; the disease is preeclampsia.