This study was aimed: 1) to explore the expression of adipoR2 in the heart and the expression of adipoR1 in aorta in type 2 diabetic rats induced by high-fat and high-sugar diet and intraperitoneal injection of a low dose of streptozotocin (STZ); 2) to investigate the effect of telmisartan on the expression of adipoR2 and NADPH oxidase subunits in the heart and the expression of adipoR1 in aorta in type 2 diabetic rats. This evidence concerns the gene ADIPOR1 and type 2 diabetes mellitus.