Thus, the purpose of this study was to assess the effect of hypercholesterolemic LDL and hypertrigliceridemic VLDL dose on LRP1 expression in cardiomyocytes, as well as the potential correlation between LRP1 expression and neutral lipid accumulation in the left ventricle tissue from patients with ischemic cardiomyopathy. The gene discussed is LRP1; the disease is ischemic cardiomyopathy.