MAL and neoplasm: These molecules include matrix metalloproteinase 11 (MMP11), CD20, Bcl2, MAL, HLA class II and Ki67, as well as cells within the CHL microenvironment, such as tumor-associated macrophages or subsets of tumor-infiltrating lymphocytes, including FOXP3+ regulatory T cells (Tregs) and granzyme B + T/NK cells [5-10].