DYRK1A and Down syndrome: Several of the miRNAs that were significantly deregulated in this comparison have been associated with non-tumor diseases including miR-144* that is overexpressed in patients with active tuberculosis (TB) [20], miR-1246 that seems to play a role in the downregulation of the Down Syndrome-associated DYRK1A [21] and miR-216a that was deregulated in mouse kidney with diabetic nephropathy [22].