A further validation of the use of immunosensitivity in making an accurate pathological diagnosis comes from the immunoanalysis studies by van Velthuysen et al. [7]: a strong positive staining for new markers of gastric metastasis like alpha-ER, PR and negative E-cadherin (P < 0.001) help differentiate this condition from gastric adenocarcinoma. The gene discussed is ESR1; the disease is gastric adenocarcinoma.