TARDBP and amyotrophic lateral sclerosis: Six years ago, TDP-43 was identified as one of the primary constituents of these inclusions in ALS and a related neurodegenerative disorder, Fronto-temporal lobar dementia with ubiquitin-positive inclusions (FTLD-U) (Neumann et al. 2006), thus spurring a new age of research into the etiology of this devastating family of diseases.