ESPL1 and chronic myelogenous leukemia, BCR-ABL1 positive: Since Separase is one of the master key players in centriole duplication, and overexpression has been associated with formation of supernumerary centrosomes in cancers including CML [18], [23], [30], [36], we investigated the influence of BCR-ABL TK on separase in the therapeutic context of IM.