Figure 6C shows that the tumor mass in mice injected with Ad-TSC-22 was remarkably reduced compared to tumors injected with Ad-LacZ or that were untreated. We next investigated the effect of TSC-22 on p53 stabilization in tumor tissues harvested from control and TSC-22 treated mice. TSC-22 transfection was observed to significantly increase the expression level of p53 protein (Figure 6D). This evidence concerns the gene TP53 and neoplasm.