The detailed mechanisms of the tumor suppressor function of TSC22 have been reported along with the hypothesis that TSC-22 represses the expression of the anti-apoptotic genes Gadd45b and Lzts2[11], negatively regulates Ras/Raf signaling [14] and involved in the TGF-b-mediated gastric carcinoma cell death in a caspase3-dependent manner [10]. Here, TSC22D1 is linked to gastric carcinoma.