For example, the average daily dose at 24 weeks after insulin initiation was less than 10.0 U/day, and less than 20% of patients achieved HbA1c levels of 7.0% or lower in the Add-on Lantus® to Oral Hypoglycemic Agents (ALOHA) study: a 24-week, prospective, open-label, multicenter, observational assessment of the safety and effectiveness of basal supported oral therapy (BOT) with insulin glargine for treating Japanese patients with type 2 diabetes in a routine clinical setting [4]. Here, INS is linked to type 2 diabetes mellitus.