At this time point, CD44-KD and CD147-KD xenografts both showed significantly reduced tumor weights compared to control groups (789±192 mg for PC-3M-luc-CD44-KD and 892±238 mg for PC-3M-luc-CD147-KD versus 1369±117 mg for PC-3M-luc and 1376±250 mg for PC-3M-luc-scr, respectively). The gene discussed is CD44; the disease is neoplasm.