CD147 (extracellular matrix metalloproteinase inducer protein-EMMPRIN) is a multifunctional glycoprotein that can modify tumor microenvironment by activating proteinases, inducing angiogenic factors in both tumor and stromal cells, and regulating growth and survival of anchorage-independent tumor cells (micrometastases) as well as multidrug resistance [18]. This evidence concerns the gene BSG and neoplasm.