INS and type 2 diabetes mellitus: A recent clinical study using insulin-free, metformin-based regimens to achieve durable glycaemic control, defined by glycated haemoglobin level of less than 8%, in young patients with type 2 diabetes, confirmed the expected from assisted reproduction gender-related effectiveness of the treatment and highlighted the complex nature of primary patient response leading to loss of glycaemic control or sustained metabolic decompensation requiring insulin administration [41].