Recent guidelines for the glycaemic control of ICU patients with severe sepsis recommend the use of validated protocols for insulin dose adjustment to maintain blood glucose < 150 mg/dL (8.3mmol/L) [31, 32] Implementation of analogous insulin infusion algorithms to secure tight insulin control in a broader spectrum of critically ill patients in the ICU however, led to increased rates of hypoglycaemia of unclear clinical significance [33]. This evidence concerns the gene INS and Sepsis.