Secondly, the recent finding that inhibition of PKC θ increases the suppressive activity of regulatory T cells (Zanin-Zhorov et al., 2010) suggests that therapeutic strategies designed to inhibit this kinase may hold great promise in diverting the pro/anti-inflammatory balance toward a reduction in inflammation in T cell autoimmunity and allergy, whilst at the same time maintaining immunity to viral pathogens. Here, PRRT2 is linked to allergic disease.