In neovascularization, observed in ischemia, tumor growth and inflammatory conditions, infiltrating cells from the myeloid lineage, such as macrophages, are key players [24–26] as an abundant source of angiogenic factors [1, 24, 27], notably vascular endothelial growth factor (VEGF), interleukin 1β, TNF-α, and interleukin 6 [27]. The gene discussed is VEGFA; the disease is ischemia.