In other studies, α, β-amyrin ameliorated periodontal inflammation in rat model of ligature-induced periodontitis reducing the neutrophil infiltration, oxidative stress and the production of proinflammatory cytokine TNF- α,[10] and exhibited long-lasting antinociceptive and anti-inflammatory properties in 2 models of persistent nociception via activation of cannabinoid receptors and by inhibiting the production of cytokines and expression of NF-κB, and cyclooxygenase 2[12,13]. Here, TNF is linked to periodontitis.