As shown in Figure 2, patients with active AOSD had significantly higher median levels of serum IL-6 (median = 474.81 pg/mL, IQ range 156.42 pg/mL to 987.55 pg/mL), IL-17A (median = 306.80 pg/mL, IQ range 152.17 pg/mL to 503.70 pg/mL) and TNF-α (median = 51.85 pg/mL, IQ range 23.63 pg/mL to 65.93 pg/mL) compared with those in HCs (median = 85.78 pg/mL, IQ range 31.13 pg/mL to 189.98 pg/mL, P <0.001 for IL-6; median = 70.90 pg/mL, IQ range 51.42 pg/mL to 124.53 pg/mL, P <0.001 for IL-17A; and median = 24.66 pg/mL, IQ range 10.50 pg/mL to 37.76 pg/mL, P <0.01 for TNF-α). Here, TNF is linked to adult-onset Still disease.