Although in Eca109 cells, over expression of miR-101 was found to suppress EZH2 expression, we did not detect significant correlation between the expression of miR-101 and EZH2 in clinical samples of ESSC tumor tissues and we found that miR-101-induced inhibition of Eca109 migration and invasion was not reversed by overexpressing EZH2. The gene discussed is EZH2; the disease is neoplasm.