EZH2 and esophageal squamous cell carcinoma: In summary, we have demonstrated that the expression of miR-98 and miR-214 was significantly lower in ESCC tissues than in matched normal tissues and that down-regulation of miR-98 and miR-214 was correlated with the up-regulated EZH2 protein expression, poor pathological grade, advanced tumor stage and lymph node metastasis in ESCC.