In the present study, we found that miR-98 and miR-214 expression were both inversely correlated with EZH2 protein expression in human ESCC, and that down-regulation of miR-98 and miR-214 expression was significantly correlated with pathological grading, tumor stage and lymph node metastasis. Here, EZH2 is linked to esophageal squamous cell carcinoma.