With respect to DNA synthesis genes, low expression of ribonucleotide reductase M1 (RRM1), one of the two subunits of an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells, was associated with clinical benefit from neoadjuvant cisplatin/gemcitabine in NSCLC patients [7,11,16]. This evidence concerns the gene RRM1 and non-small cell lung carcinoma.