Although ANGPTL-4 was identified in a gene expression profiling analysis as one of the most highly expressed genes in early CIA (day 28), this expression subsided with time (day 49) [43] - perhaps suggesting that RA FLS lose the ability to express ANGPTL-4 as disease progresses, with possible impact on blood vessel formation. This evidence concerns the gene ANGPTL4 and rheumatoid arthritis.