Once we had established the relative contribution of HIF isoforms to the hypoxic induction of the adipokines and EFNA3 in RA FLS, we proceeded to investigate the regulation of HIFs by cytokines alone and in combination with hypoxia, as has been done before for HIF-1 and Th1 cytokines [21] but not for Th2 cytokines and HIF-2. The gene discussed is HIF1A; the disease is rheumatoid arthritis.