PDPN and metastatic malignant neoplasm in the lymph nodes: To overcome this limitation, Ishii et al.[19] recommended the use of immunostaining with some materials such as monoclonal antibody D2-40 demonstrating that such method would provide important information about the risk of lymph node metastasis and may prove useful in evaluating the necessity of an additional resection after local excision in T1 CRCs.