NFE2L2 and cancer: The activation of the NRF2-mediated antioxidant pathway is a clear point of focus for future work; especially as activating NRF2 mutations and inactivating KEAP1 mutations are prevalent in many cancer types (Hayes and McMahon, 2009) and oncogene-induced Nrf2 transcription promotes tumorigenesis in mice (DeNicola et al., 2011).