In summary, our results provide new insights into the roles of MUC1 in the metastatic adhesion cascade and suggests future examination into clinical aspects where the underglycosylated form of MUC1 can be targeted since aberrantly underglycosylated MUC1 expression is highly correlated to poor prognosis in breast and colon cancer patients. Here, MUC1 is linked to colonic neoplasm.