Vitamin D was demonstrated to be essential for IFN-γ-induced responses in monocytic cells which includes conversion of 25(OH)D to active 1,25(OH)2D, activation of VDR, induction of host defence peptides i.e. cathelicidin and defensins, autophagy and phagosome maturation, collectively contributing to the control of TB [33]. This evidence concerns the gene VDR and tuberculosis.