CSF1R and neoplasm: Since both MDSCs and BMSCs suppress T cell proliferation/function to subvert immune surveillance and prevent the immune system from eliminating tumor cells [34–36,44,45], whether bone marrow-derived BMSCs participate in organ pathogenic development along with MDSCs in lal−/− mice and c-fms-rtTA/(TetO)7-CMV-Stat3C bitransgenic mice is an intriguing idea and remains to be tested in the future.