In the discovery stage of another genome-wide scanning study, CSF3R and ERCC1 gene methylation was identified as a biomarker of small-cell lung cancer using a methylation array of 1505 CpG sites in 39 small-cell lung cancer cases and 44 matched controls, which was validated in an independent set of 138 matched case-control pairs using pyrosequencing.65 Pedersen et al17 conducted a 2-phase study using the GoldenGate methylation Beadchip for phase I and the Illumina custom VeraCode methylation assay for phase II in 220 pairs of cases and controls. Here, ERCC1 is linked to small cell lung carcinoma.