Absence of a PKD2 mutation was associated with a non-significant trend towards a greater hazard of developing CKD3, (HR 1.45; 0.68-3.07, P = 0.33, Figure 4) even when adjusting the model for gender and hypertension (HR 1.54; 0.73-3.29, P = 0.26) (Additional file 2: Table S2). The gene discussed is PKD2; the disease is hypertensive disorder.