MKI67 and invasive carcinoma: In addition to FGFR1 amplification, high T stage (T1 to T2 vs. T3 to T4, P < 0.001), nodal metastasis (N0 vs. N1 to N3, P = 0.002), hormone receptor negativity (P = 0.004), p53 overexpression (P = 0.005) and high Ki-67 proliferation index (P = 0.006) were significantly associated with poor disease-free survival in all patients with invasive carcinoma.