ERBB2 and breast cancer: While higher numbers of gains/losses have been associated with the basal-like subtype, high-level DNA amplification has been found in the luminal B and HER2-positive subtypes [48], and candidate oncogenes have been identified in chromosomal regions 1q21-23, 10p14 and 12p13 for basal-like breast cancers, but in regions 1q21-23, 8p12-q21, 11q13 and 16p12-13 for luminal breast cancers [4].